Proteomics

Dataset Information

0

CML proteome analysis, TripleTOF 5600


ABSTRACT: Using mass spectrometry the proteomes of CML were compared to normal tissue.

OTHER RELATED OMICS DATASETS IN: PRJNA112367PRJNA132313PRJNA208363PRJNA96045

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Cell, Blood

DISEASE(S): Chronic Myeloid Leukemia

SUBMITTER: Andrew Williamson  

LAB HEAD: Anthony David Whetton

PROVIDER: PXD001504 | Pride | 2016-06-03

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
5600CML_Cyto_1_MGFPeaklist.mgf Mgf
CML_Cyto_1.mzXML Mzxml
CML_Cyto_1.xml Xml
CML_Cyto_10.mzXML Mzxml
CML_Cyto_11.mzXML Mzxml
Items per page:
1 - 5 of 49
altmetric image

Publications


Chronic myeloid leukaemia (CML) arises after transformation of a haemopoietic stem cell (HSC) by the protein-tyrosine kinase BCR-ABL. Direct inhibition of BCR-ABL kinase has revolutionized disease management, but fails to eradicate leukaemic stem cells (LSCs), which maintain CML. LSCs are independent of BCR-ABL for survival, providing a rationale for identifying and targeting kinase-independent pathways. Here we show--using proteomics, transcriptomics and network analyses--that in human LSCs, ab  ...[more]

Similar Datasets

2016-06-03 | PXD001502 | Pride
2016-06-03 | PXD001503 | Pride
2016-05-26 | E-MTAB-2581 | biostudies-arrayexpress
2011-05-10 | E-GEOD-26260 | biostudies-arrayexpress
2009-12-05 | E-GEOD-17480 | biostudies-arrayexpress
2021-11-08 | GSE188241 | GEO
2014-08-31 | GSE60065 | GEO
2014-04-17 | E-GEOD-40721 | biostudies-arrayexpress
2016-11-01 | E-MTAB-3552 | biostudies-arrayexpress
2018-01-12 | E-MTAB-3220 | biostudies-arrayexpress