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Global proteome changes in liver tissue 6 weeks after FOLFOX treatment of colorectal cancer liver metastases.

ABSTRACT: Study: Oxaliplatin-based chemotherapy for colorectal liver metastasis is associated with sinusoidal injury of liver parenchyma and may result in increased morbidity after liver surgery. Preclinical and human liver parenchyma studies have proposed several pathways of oxaliplatin-induced injury, but the effects on protein level remains unknown. Protein expression in liver tissue from eight patients treated with FOLFOX and seven controls without treatment was analyzed by label-free liquid chromatography mass spectrometry. Conclusion: Six weeks after FOLFOX treatment less than 1% of identified proteins showed changes in expression. The changes were associated with DNA replication, cell cycle entry and innate immune response. We hypothesize that the changes are residual after recovery from FOLFOX treatment injury.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Liver

DISEASE(S): Colon Cancer

SUBMITTER: Mario Oroshi

LAB HEAD: Jacek R Wisniewski

PROVIDER: PXD001889 | Pride | 2016-12-14

REPOSITORIES: pride

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			Action	DRS
	20130122_EXQ4_JRW_B52_1_L.raw	Raw
	20130122_EXQ4_JRW_B52_1_T.raw	Raw
	20130122_EXQ4_JRW_B52_2_L.raw	Raw
	20130122_EXQ4_JRW_B52_2_T.raw	Raw
	20130122_EXQ4_JRW_B53_1_L.raw	Raw

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