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Puniya2021 - CD4+ Th17 cell metabolism model

ABSTRACT: CD4+ T cells are critical components in the human immune system. They produce cytokines to fight against pathogens and abnormal cells and stimulate other cells, such as B cells, macrophages, and neutrophils, to generate an immune response. T helper 17 (Th17) cells are subtype CD4+ T cells that differentiate from naive CD4+ T cells in a specific cytokine environment. The Th17 cell model consists of 5282 reactions, 3263 metabolites, and 1250 genes. CD4+ T cell models helped identify drug targets and repurposable drugs against autoimmune diseases.

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

SUBMITTER: Bhanwar Lal Puniya  

PROVIDER: MODEL1909260006 | BioModels | 2023-11-27

REPOSITORIES: BioModels

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MODEL1909260006?filename=FROG.omex Other
MODEL1909260006?filename=MemoteReport.html Other
MODEL1909260006?filename=Puniya2021_T17M1250.xml Xml
MODEL1909260006?filename=T17M1250.fbc2.xml Xml
MODEL1909260006?filename=miniFROG_T17M1250_Th17.xlsx Xlsx
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Publications

Integrative computational approach identifies drug targets in CD4<sup>+</sup> T-cell-mediated immune disorders.

Puniya Bhanwar Lal BL   Amin Rada R   Lichter Bailee B   Moore Robert R   Ciurej Alex A   Bennett Sydney J SJ   Shah Ab Rauf AR   Barberis Matteo M   Helikar Tomáš T  

NPJ systems biology and applications 20210122 1

CD4<sup>+</sup> T cells provide adaptive immunity against pathogens and abnormal cells, and they are also associated with various immune-related diseases. CD4<sup>+</sup> T cells' metabolism is dysregulated in these pathologies and represents an opportunity for drug discovery and development. Genome-scale metabolic modeling offers an opportunity to accelerate drug discovery by providing high-quality information about possible target space in the context of a modeled disease. Here, we develop gen  ...[more]

PMID: 33483502

Publication: 1/596

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