Ontology highlight
ABSTRACT:
INSTRUMENT(S): Progenesis LC-MS, Dionex instrument model, Mascot, LTQ Orbitrap Elite
ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast)
SUBMITTER: David Talavera
LAB HEAD: Graham Pavitt
PROVIDER: PXD001903 | Pride | 2016-04-13
REPOSITORIES: Pride
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Kershaw Christopher J CJ Costello Joseph L JL Talavera David D Rowe William W Castelli Lydia M LM Sims Paul F G PF Grant Christopher M CM Ashe Mark P MP Hubbard Simon J SJ Pavitt Graham D GD
Scientific reports 20151023
The PUF family of RNA-binding proteins regulate gene expression post-transcriptionally. Saccharomyces cerevisiae Puf3p is characterised as binding nuclear-encoded mRNAs specifying mitochondrial proteins. Extensive studies of its regulation of COX17 demonstrate its role in mRNA decay. Using integrated genome-wide approaches we define an expanded set of Puf3p target mRNAs and quantitatively assessed the global impact of loss of PUF3 on gene expression using mRNA and polysome profiling and quantita ...[more]