Dataset Information

Proteome alterations associated with transformation of multiple myeloma to secondary plasma cell leukemia

ABSTRACT: Plasma cell leukemia is a rare and aggressive plasma cell neoplasm that may either originate de novo (primary PCL) or by leukemic transformation of multiple myeloma (MM) to secondary PCL (sPCL). The prognosis of sPCL is very poor, and currently no standard treatment is available due to lack of prospective clinical studies. In an attempt to elucidate factors contributing to transformation, we have performed quantitative proteome profiling of malignant plasma cells collected from the same patient at both the MM and sPCL stages of the disease.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): B Cell, Bone Marrow, Blood

DISEASE(S): Multiple Myeloma

SUBMITTER: Animesh Sharma

LAB HEAD: Geir Slupphaug

PROVIDER: PXD001963 | Pride | 2017-05-02

REPOSITORIES: Pride

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Proteome alterations associated with transformation of multiple myeloma to secondary plasma cell leukemia.

Zatula Alexey A Dikic Aida A Mulder Celine C Sharma Animesh A Vågbø Cathrine B CB Sousa Mirta M L MML Waage Anders A Slupphaug Geir G

Oncotarget 20170301 12

Plasma cell leukemia is a rare and aggressive plasma cell neoplasm that may either originate de novo (primary PCL) or by leukemic transformation of multiple myeloma (MM) to secondary PCL (sPCL). The prognosis of sPCL is very poor, and currently no standard treatment is available due to lack of prospective clinical studies. In an attempt to elucidate factors contributing to transformation, we have performed super-SILAC quantitative proteome profiling of malignant plasma cells collected from the s ...[more]

PMID: 28038447

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