Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PRJNA281173
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Permanent Cell Line Cell, Cell Culture
DISEASE(S): Cervix Carcinoma
SUBMITTER: Zhe Cheng
LAB HEAD: Christine Vogel
PROVIDER: PXD002039 | Pride | 2016-03-14
REPOSITORIES: Pride
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1_0h_RS1_CYT_120420.raw | Raw | |||
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1_0h_RS1_CYT_120425.raw | Raw | |||
1_0h_RS1_CYT_120427.raw | Raw | |||
1_0h_RS1_NF_120430.raw | Raw |
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Molecular systems biology 20160120 1
The relative importance of regulation at the mRNA versus protein level is subject to ongoing debate. To address this question in a dynamic system, we mapped proteomic and transcriptomic changes in mammalian cells responding to stress induced by dithiothreitol over 30 h. Specifically, we estimated the kinetic parameters for the synthesis and degradation of RNA and proteins, and deconvoluted the response patterns into common and unique to each regulatory level using a new statistical tool. Overall ...[more]