Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Drosophila Melanogaster (fruit Fly)
TISSUE(S): Embryo, Early Embryonic Cell
SUBMITTER: Michael Götze
LAB HEAD: Elmar Wahle
PROVIDER: PXD006596 | Pride | 2017-07-18
REPOSITORIES: Pride
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Götze Michael M Dufourt Jérémy J Ihling Christian C Rammelt Christiane C Pierson Stephanie S Sambrani Nagraj N Temme Claudia C Sinz Andrea A Simonelig Martine M Wahle Elmar E
RNA (New York, N.Y.) 20170712 10
Translational repression of maternal mRNAs is an essential regulatory mechanism during early embryonic development. Repression of the <i>Drosophila nanos</i> mRNA, required for the formation of the anterior-posterior body axis, depends on the protein Smaug binding to two Smaug recognition elements (SREs) in the <i>nanos</i> 3' UTR. In a comprehensive mass spectrometric analysis of the SRE-dependent repressor complex, we identified Smaug, Cup, Me31B, Trailer hitch, eIF4E, and PABPC, in agreement ...[more]