Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Epithelial Cell, Colon, Macrophage
DISEASE(S): Colon Cancer
SUBMITTER: Tamar Geiger
LAB HEAD: Dr. Tamar Geiger
PROVIDER: PXD002094 | Pride | 2016-09-26
REPOSITORIES: Pride
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The Journal of experimental medicine 20161003 11
Tumor-associated macrophages (TAMs) promote tumor development, invasion, and dissemination by various mechanisms. In this study, using an orthotopic colorectal cancer (CRC) model, we found that monocyte-derived TAMs advance tumor development by the remodeling of its extracellular matrix (ECM) composition and structure. Unbiased transcriptomic and proteomic analyses of (a) TAM-abundant and -deficient tumor tissues and (b) sorted tumor-associated and -resident colonic macrophage subpopulations def ...[more]