Dataset Information

Proteomic Analysis of Minimally Damaged Renal Tubular Tissue from Two-Kidney-One-Clip Hypertensive Rats Demonstrates Extensive Changes Compared to Tissue from Controls

ABSTRACT: Tubular atrophy and interstitial fibrosis present the final stage in most forms of progressive kidney diseases. Little is known regarding the early changes in the tubular proteome. In this study, we investigated changes in the tubular proteome of normal or near-normal tubular tissue in the non-clipped kidney from rats with two-kidney one-clip (2K1C) hypertension

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Epithelial Cell, Kidney

DISEASE(S): Renovascular Hypertension

SUBMITTER: Kenneth Finne

LAB HEAD: Kenneth Finne

PROVIDER: PXD002106 | Pride | 2015-12-23

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	FFPE_TUBULI_2K1C-1.raw	Raw
	FFPE_TUBULI_2K1C-2.raw	Raw
	FFPE_TUBULI_2K1C-3.raw	Raw
	FFPE_TUBULI_2K1C-4.raw	Raw
	FFPE_TUBULI_2K1C_SHAM_1-10.mzid.gz	Mzid

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Publications

Proteomic Analysis of Minimally Damaged Renal Tubular Tissue from Two-Kidney-One-Clip Hypertensive Rats Demonstrates Extensive Changes Compared to Tissue from Controls.

Finne Kenneth K Marti Hans-Peter HP Leh Sabine S Skogstrand Trude T Vethe Heidrun H Tenstad Olav O Berven Frode S FS Scherer Andreas A Vikse Bjørn Egil BE

Nephron 20160109 1

<h4>Background</h4>Tubular atrophy and interstitial fibrosis mark the final stage in most forms of progressive kidney diseases. Little is known regarding changes in the tubular proteome. In this study, we investigated changes in the tubular proteome of normal or minimally damaged tubular tissue in the non-clipped kidney from rats with two-kidney one-clip (2K1C) hypertension.<h4>Methods</h4>Formalin-fixed paraffin-embedded kidney sections from four 2K1C rats with hypertensive kidney damage and 6 ...[more]

PMID: 26745798

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