C. elegans SGK-1 IP-MS - Serum- and Glucocorticoid-Inducible Kinase-1 (SGK-1) Plays a Role in Membrane Trafficking in Caenorhabditis elegans
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Caenorhabditis Elegans
TISSUE(S): Whole Body, Diploid Cell
DISEASE(S): Disease Free
SUBMITTER: 
Ming Zhu
LAB HEAD: Meng-Qiu Dong
PROVIDER: PXD002190 | Pride | 2015-06-29
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| SGK-1_IP_MS_rep-1.RAW.gz | Raw | |||
| SGK-1_IP_MS_rep-2.RAW.gz | Raw | |||
| result_SGK-1_IP_MS_rep-1.html | Other | |||
| result_SGK-1_IP_MS_rep-2.html | Other |
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Publications
Serum- and Glucocorticoid-Inducible Kinase-1 (SGK-1) Plays a Role in Membrane Trafficking in Caenorhabditis elegans.
Zhu Ming M Wu Gang G Li Yu-Xin YX Stevens Julia Kathrin JK Fan Chao-Xuan CX Spang Anne A Dong Meng-Qiu MQ
PloS one 20150626 6
The mammalian serum- and glucocorticoid-inducible kinase SGK1 regulates the endocytosis of ion channels. Here we report that in C. elegans sgk-1 null mutants, GFP-tagged MIG-14/Wntless, the sorting receptor of Wnt, failed to localize to the basolateral membrane of intestinal cells; instead, it was mis-sorted to lysosomes. This effect can be explained in part by altered sphingolipid levels, because reducing glucosylceramide biosynthesis restored the localization of MIG-14::GFP. Membrane traffic w ...[more]
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