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Proteome and pathway effects of chronic haoperidol treatment in mouse hippocampus

ABSTRACT: Seven male C57BL/6 mice, at 10 weeks of age, were injected daily intraperitoneally with 0.5 mg/kg of haloperidol, for 28 days. A control group of six animals was injected with vehicle only (saline).

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain

SUBMITTER: Melanie Foecking

LAB HEAD: David Richard Cotter

PROVIDER: PXD002250 | Pride | 2015-11-30

REPOSITORIES: Pride

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	120117kw_Oliver_M01_120119173152.RAW	Raw
	120117kw_Oliver_M02_120119202704.RAW	Raw
	120117kw_Oliver_M03_120120005838.RAW	Raw
	120117kw_Oliver_M04_120120035311.RAW	Raw
	120117kw_Oliver_M05_120120064744.RAW	Raw

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Proteome and pathway effects of chronic haloperidol treatment in mouse hippocampus.

Schubert Klaus Oliver KO Föcking Melanie M Wynne Kieran K Cotter David R DR

Proteomics 20160113 3

Proteomic exploration of the effects of psychotropic drugs on specific brain areas in rodents has the potential to uncover novel molecular networks and pathways affected by psychotropic medications, and may inform etiologic hypotheses on mental disorders. Haloperidol, a widely used first-generation antipsychotic, has been shown to produce structural and functional changes of the hippocampus, a brain region also implicated in the neuropathology of disorders such as schizophrenia and bipolar disor ...[more]

PMID: 26607048

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