Proteomics

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Proteome and pathway effects of chronic haoperidol treatment in mouse hippocampus


ABSTRACT: Seven male C57BL/6 mice, at 10 weeks of age, were injected daily intraperitoneally with 0.5 mg/kg of haloperidol, for 28 days. A control group of six animals was injected with vehicle only (saline).

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain

SUBMITTER: Melanie Foecking  

LAB HEAD: David Richard Cotter

PROVIDER: PXD002250 | Pride | 2015-11-30

REPOSITORIES: Pride

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Proteome and pathway effects of chronic haloperidol treatment in mouse hippocampus.

Schubert Klaus Oliver KO   Föcking Melanie M   Wynne Kieran K   Cotter David R DR  

Proteomics 20160113 3


Proteomic exploration of the effects of psychotropic drugs on specific brain areas in rodents has the potential to uncover novel molecular networks and pathways affected by psychotropic medications, and may inform etiologic hypotheses on mental disorders. Haloperidol, a widely used first-generation antipsychotic, has been shown to produce structural and functional changes of the hippocampus, a brain region also implicated in the neuropathology of disorders such as schizophrenia and bipolar disor  ...[more]

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