Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF, LTQ Orbitrap Elite
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Brain
SUBMITTER: Chao Peng
LAB HEAD: Chao Peng
PROVIDER: PXD037994 | Pride | 2023-02-02
REPOSITORIES: Pride
Zhang Shujing S Zhu Ruowei R Pan Buyan B Xu Hong H Olufemi Modupe F MF Gathagan Ronald J RJ Li Yuanxi Y Zhang Luyan L Zhang Jasmine J Xiang Wenxuan W Kagan Eliot Masahiro EM Cao Xingjun X Yuan Chaoxing C Kim Soo-Jung SJ Williams Christopher K CK Magaki Shino S Vinters Harry V HV Lashuel Hilal A HA Garcia Benjamin A BA James Petersson E E Trojanowski John Q JQ Lee Virginia M-Y VM Peng Chao C
Nature neuroscience 20230123 2
Cell-to-cell transmission and subsequent amplification of pathological proteins promote neurodegenerative disease progression. Most research on this has focused on pathological protein seeds, but how their normal counterparts, which are converted to pathological forms during transmission, regulate transmission is less understood. Here we show in cultured cells that phosphorylation of soluble, nonpathological α-synuclein (α-Syn) at previously identified sites dramatically affects the amplificatio ...[more]