Proteomics

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SLC12A3 isoforms in human urine exosomes

ABSTRACT: The thiazide-sensitive NaCl cotransporter (NCC) is an important pharmacological target in the treatment of hypertension. Human SLC12A3 gene encoding NCC gives rise to three isoforms. Only the isoform 3 has been extensively investigated. The goal of the present study was, therefore, to determine the abundance and localization of NCC1 and NCC2 in comparison to NCC3 in the human kidney as well as their functional properties in physiological and pathological conditions. To this end, the presence of NCC1, NCC2, and NCC3 in the human urinary exosomes was assessed by mass spectrometric analysis.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Urine, Bladder Urothelial Cell

DISEASE(S): Hypertension

SUBMITTER: Sander Piersma  

LAB HEAD: Connie Ramona Jimenez

PROVIDER: PXD002279 | Pride | 2016-06-14

REPOSITORIES: Pride

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Dataset's files

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QE1_150213_OPL4021_TRAS_SLC12A3_L1.raw Raw
QE1_150213_OPL4021_TRAS_SLC12A3_L2.raw Raw
QE1_150213_OPL4021_TRAS_SLC12A3_L3.raw Raw
QE1_150213_OPL4021_TRAS_SLC12A3_L4.raw Raw
QE1_150213_OPL4021_TRAS_SLC12A3_L5.raw Raw
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Publications

Alternative splice variant of the thiazide-sensitive NaCl cotransporter: a novel player in renal salt handling.

Tutakhel Omar A Z OA   Jeleń Sabina S   Valdez-Flores Marco M   Dimke Henrik H   Piersma Sander R SR   Jimenez Connie R CR   Deinum Jaap J   Lenders Jacques W JW   Hoenderop Joost G J JG   Bindels René J M RJ  

American journal of physiology. Renal physiology 20151111 3

The thiazide-sensitive NaCl cotransporter (NCC) is an important pharmacological target in the treatment of hypertension. The human SLC12A3 gene, encoding NCC, gives rise to three isoforms. Only the third isoform has been extensively investigated. The aim of the present study was, therefore, to establish the abundance and localization of the almost identical isoforms 1 and 2 (NCC1/2) in the human kidney and to determine their functional properties and regulation in physiological conditions. Immun  ...[more]

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