Dataset Information

Reproductive aging drives protein accumulation in the uterus and limits lifespan in C. elegans

ABSTRACT: We identify changes in the C. elegans proteome that occur with increased age. We find that secreted proteins and proteins specifically expressed in adult animals tend to increase in abundance with age. A subset of these proteins is solely expressed in the extracellular space of the adult uterus. These uterine protiens are rapidly turned over in yound adult animals, but are removed much more slowly in old worms. The dataset presented here describes the quantification of protein abundance in young and old adult worms as measured by LC-MS/MS.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Caenorhabditis Elegans

TISSUE(S): Whole Body

SUBMITTER: Izumi Hinkson

LAB HEAD: Josh Elias

PROVIDER: PXD002432 | Pride | 2018-10-24

REPOSITORIES: Pride

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Reproductive Aging Drives Protein Accumulation in the Uterus and Limits Lifespan in C. elegans.

Zimmerman Stephanie M SM Hinkson Izumi V IV Elias Joshua E JE Kim Stuart K SK

PLoS genetics 20151211 12

Aging in Caenorhabditis elegans is characterized by widespread physiological and molecular changes, but the mechanisms that determine the rate at which these changes occur are not well understood. In this study, we identify a novel link between reproductive aging and somatic aging in C. elegans. By measuring global age-related changes in the proteome, we identify a previously uncharacterized group of secreted proteins in the adult uterus that dramatically increase in abundance with age. This acc ...[more]

PMID: 26656270

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