Dataset Information

Cathepsin B interstitial fluid proteome of murine breast cancers

ABSTRACT: MS-based proteomics study of the interstitial fluid of breast cancer of mice lacking or overexpressing cathepsin B

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus Musculus (mouse)

DISEASE(S): Breast Cancer

SUBMITTER: Alejandro Gomez-Auli

LAB HEAD: Oliver Schilling

PROVIDER: PXD002585 | Pride | 2016-03-31

REPOSITORIES: Pride

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Impact of cathepsin B on the interstitial fluid proteome of murine breast cancers.

Gomez-Auli Alejandro A Hillebrand Larissa Elisabeth LE Biniossek Martin Lothar ML Peters Christoph C Reinheckel Thomas T Schilling Oliver O

Biochimie 20151008

Carcinomas establish a molecular cross talk between malignant tumor cells and the activated non-malignant cells of the tumor stroma. This cell-cell communication in tumor-stroma interaction includes soluble, secreted proteins that act in a paracrine or autocrine manner. Proteases are crucial factors in tumor-stroma interaction by degrading or truncating secreted bioactive proteins. The cysteine protease cathepsin B is frequently overexpressed in several cancer types, including breast cancer. Its ...[more]

PMID: 26455267

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