Dataset Information

Phosphoproteome of airway epithelial cell in response to infection with Staphylococcus aureus

ABSTRACT: Here we used an unbiased proteomic and phosphoproteomic approach to characterize the response of 16HBE14o- airway epithelial cells following infection with S. aureus.

OTHER RELATED OMICS DATASETS IN: PRJNA272720

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Cell Culture

SUBMITTER: Erik Richter

LAB HEAD: Falko Hochgräfe

PROVIDER: PXD002776 | Pride | 2016-12-14

REPOSITORIES: Pride

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			Action	DRS
	140516_V3_P5_JMO_Phosphoexp-2-4_120-10_I.raw	Raw
	140516_V3_P5_JMO_Phosphoexp-2-4_120-1_I.raw	Raw
	140516_V3_P5_JMO_Phosphoexp-2-4_120-2_I.raw	Raw
	140516_V3_P5_JMO_Phosphoexp-2-4_120-3_I.raw	Raw
	140516_V3_P5_JMO_Phosphoexp-2-4_120-4_I.raw	Raw

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Publications

Quantitative Proteomics Reveals the Dynamics of Protein Phosphorylation in Human Bronchial Epithelial Cells during Internalization, Phagosomal Escape, and Intracellular Replication of Staphylococcus aureus.

Richter Erik E Harms Manuela M Ventz Katharina K Nölker Rolf R Fraunholz Martin J MJ Mostertz Jörg J Hochgräfe Falko F

Journal of proteome research 20161104 12

Internalization of Staphylococcus aureus by nonprofessional phagocytic cells is a major suspected cause of persistent and difficult-to-treat infections, including pneumonia. In this study, we established an infection model with 16HBE14o- human bronchial epithelial cells and demonstrated internalization, escape from phagosomal clearance, and intracellular replication of S. aureus HG001 within the first 4 h postinfection. We used quantitative phosphoproteomics to identify characteristic signaling ...[more]

PMID: 27762562

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