Dataset Information

Repairing oxidatively damaged proteins using electrons from the respiratory chain

ABSTRACT: The reactive species of oxygen (ROS) and chlorine (RCS) damage cellular components, potentially leading to cell death. In proteins, the sulfur-containing amino acid methionine (Met) is converted to methionine sulfoxide (Met-O), which can cause a loss of biological activity.

INSTRUMENT(S): LTQ

ORGANISM(S): Escherichia Coli

SUBMITTER: Didier Vertommen

LAB HEAD: Jean-François Collet

PROVIDER: PXD002804 | Pride | 2015-09-16

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	BCHM220_Ctrl_Metonly_MultiConsensus.pep.xml	Pepxml
	BCHM220_Ctrl_frac1.RAW	Raw
	BCHM220_Ctrl_frac1.msf	Msf
	BCHM220_Ctrl_frac10.RAW	Raw
	BCHM220_Ctrl_frac10.msf	Msf

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Publications

Repairing oxidized proteins in the bacterial envelope using respiratory chain electrons.

Gennaris Alexandra A Ezraty Benjamin B Henry Camille C Agrebi Rym R Vergnes Alexandra A Oheix Emmanuel E Bos Julia J Leverrier Pauline P Espinosa Leon L Szewczyk Joanna J Vertommen Didier D Iranzo Olga O Collet Jean-François JF Barras Frédéric F

Nature 20151207 7582

The reactive species of oxygen and chlorine damage cellular components, potentially leading to cell death. In proteins, the sulfur-containing amino acid methionine is converted to methionine sulfoxide, which can cause a loss of biological activity. To rescue proteins with methionine sulfoxide residues, living cells express methionine sulfoxide reductases (Msrs) in most subcellular compartments, including the cytosol, mitochondria and chloroplasts. Here we report the identification of an enzymati ...[more]

PMID: 26641313

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