Dataset Information

Peptidomics of circular cysteine-rich plant peptides – Analysis of the diversity of cyclotides from Viola tricolor by transcriptome- and proteome-mining

ABSTRACT: circular peptides, cystine-knot, transcriptome, peptidomics, Violaceae, ribosomally synthesized and post-translationally modified peptides natural products, mass spectrometry, 1kp

INSTRUMENT(S): Bruker Daltonics micrOTOF series

ORGANISM(S): Viola Tricolor Subsp. Tricolor Viola Tricolor

SUBMITTER: Roland Hellinger

LAB HEAD: Christian W. Gruber

PROVIDER: PXD002867 | Pride | 2015-10-02

REPOSITORIES: Pride

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Peptidomics of Circular Cysteine-Rich Plant Peptides: Analysis of the Diversity of Cyclotides from Viola tricolor by Transcriptome and Proteome Mining.

Hellinger Roland R Koehbach Johannes J Soltis Douglas E DE Carpenter Eric J EJ Wong Gane Ka-Shu GK Gruber Christian W CW

Journal of proteome research 20151008 11

Cyclotides are plant-derived mini proteins. They are genetically encoded as precursor proteins that become post-translationally modified to yield circular cystine-knotted molecules. Because of this structural topology cyclotides resist enzymatic degradation in biological fluids, and hence they are considered as promising lead molecules for pharmaceutical applications. Despite ongoing efforts to discover novel cyclotides and analyze their biodiversity, it is not clear how many individual peptides ...[more]

PMID: 26399495

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