Proteomics

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Comparison of the Cowpox Virus and Vaccinia Virus Mature Virion Proteome: Analysis of the species- and strain-specific Proteome


ABSTRACT: Cowpox virus (CPXV) causes most zoonotic orthopoxvirus (OPV) infections in Europe and Northern as well as Central Asia. The virus has the broadest host range of OPV and is transmitted to humans from rodents and other wild or domestic animals. Increasing numbers of human CPXV infections in a population with declining immunity have raised concerns about the virus’ zoonotic potential. While there have been reports on the proteome of other human-pathogenic OPV, namely vaccinia virus (VACV) and monkeypox virus (MPXV), the protein composition of the CPXV mature virion (MV) is unknown. This study focused on the comparative analysis of the VACV and CPXV MV proteome by label-free single-run proteomics using nano liquid chromatography and high-resolution tandem mass spectrometry (nLC-MS/MS).

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Orthopoxvirus

TISSUE(S): Epithelial Cell, Cell Culture

DISEASE(S): Cowpox

SUBMITTER: Joerg Doellinger  

LAB HEAD: Andreas Nitsche

PROVIDER: PXD003013 | Pride | 2015-11-16

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
CPXVHei_Uniprotformat.fasta Fasta
CPXVKre_Uniprotformat.fasta Fasta
CPXV_BR_1.RAW Raw
CPXV_BR_2.RAW Raw
CPXV_BR_3.RAW Raw
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Publications

Comparison of the Cowpox Virus and Vaccinia Virus Mature Virion Proteome: Analysis of the Species- and Strain-Specific Proteome.

Doellinger Joerg J   Schaade Lars L   Nitsche Andreas A  

PloS one 20151110 11


Cowpox virus (CPXV) causes most zoonotic orthopoxvirus (OPV) infections in Europe and Northern as well as Central Asia. The virus has the broadest host range of OPV and is transmitted to humans from rodents and other wild or domestic animals. Increasing numbers of human CPXV infections in a population with declining immunity have raised concerns about the virus' zoonotic potential. While there have been reports on the proteome of other human-pathogenic OPV, namely vaccinia virus (VACV) and monke  ...[more]

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