Dataset Information

Mouse bone marrow derived neutrophils, LC-MSMS

ABSTRACT: Analysis of cell membrane-enriched proteins of mouse polymorphonuclear neutrophils. Further related data are present in project PXD002244.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Neutrophil, Bone Marrow

DISEASE(S): Disease Free

SUBMITTER: Blandine Lieubeau

LAB HEAD: Jean-Marie BACH

PROVIDER: PXD003015 | Pride | 2015-10-09

REPOSITORIES: Pride

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Publications

Type 1 Diabetes Prone NOD Mice Have Diminished Cxcr1 mRNA Expression in Polymorphonuclear Neutrophils and CD4+ T Lymphocytes.

Haurogné Karine K Pavlovic Marija M Rogniaux Hélène H Bach Jean-Marie JM Lieubeau Blandine B

PloS one 20150731 7

In humans, CXCR1 and CXCR2 are two homologous proteins that bind ELR+ chemokines. Both receptors play fundamental roles in neutrophil functions such as migration and reactive oxygen species production. Mouse Cxcr1 and Cxcr2 genes are located in an insulin-dependent diabetes genetic susceptibility locus. The non obese diabetic (NOD) mouse is a spontaneous well-described animal model for insulin-dependent type 1 diabetes. In this disease, insulin deficiency results from the destruction of insulin- ...[more]

PMID: 26230114

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