Proteomics

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SPE optimization for peptide sample preparation for urine peptidomics


ABSTRACT: Development of a modified solid phase extraction (SPE) approach for improved peptide yield and analysis sensitivity with LC-MS based peptidomics of urine.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Urine

SUBMITTER: Matthew Monroe  

LAB HEAD: Minnie M. Sarwal

PROVIDER: PXD003045 | Pride | 2015-10-16

REPOSITORIES: Pride

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Publications

Optimization for peptide sample preparation for urine peptidomics.

Sigdel Tara K TK   Nicora Carrie D CD   Hsieh Szu-Chuan SC   Dai Hong H   Qian Wei-Jun WJ   Camp David G DG   Sarwal Minnie M MM  

Clinical proteomics 20140225 1


Analysis of native or endogenous peptides in biofluids can provide valuable insights into disease mechanisms. Furthermore, the detected peptides may also have utility as potential biomarkers for non-invasive monitoring of human diseases. The non-invasive nature of urine collection and the abundance of peptides in the urine makes analysis by high-throughput 'peptidomics' methods , an attractive approach for investigating the pathogenesis of renal disease. However, urine peptidomics methodologies  ...[more]

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