Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite
ORGANISM(S): Escherichia Coli
SUBMITTER: Lars Leichert
LAB HEAD: Lars Ingo Ole Leichert
PROVIDER: PXD003063 | Pride | 2016-05-02
REPOSITORIES: Pride
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Müller Alexandra A Eller Jakob J Albrecht Frank F Prochnow Pascal P Kuhlmann Katja K Bandow Julia Elisabeth JE Slusarenko Alan John AJ Leichert Lars Ingo Ole LI
The Journal of biological chemistry 20160323 22
Allicin (diallyl thiosulfinate) from garlic is a highly potent natural antimicrobial substance. It inhibits growth of a variety of microorganisms, among them antibiotic-resistant strains. However, the precise mode of action of allicin is unknown. Here, we show that growth inhibition of Escherichia coli during allicin exposure coincides with a depletion of the glutathione pool and S-allylmercapto modification of proteins, resulting in overall decreased total sulfhydryl levels. This is accompanied ...[more]