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Quantitative proteomics of epithelial mesenchymal transition of human primary small airway epithelial cells: part 3

ABSTRACT: A study employs quantitative proteomics approach fro systems biology understanding of the epithelial mesenchymal transition of human primary small airway epithelial cells.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Yingxin Zhao

LAB HEAD: Yingxin Zhao, Ph.D.

PROVIDER: PXD003295 | Pride | 2018-10-25

REPOSITORIES: Pride

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Integrative proteomic analysis reveals reprograming tumor necrosis factor signaling in epithelial mesenchymal transition.

Zhao Yingxin Y Tian Bing B Sadygov Rovshan G RG Zhang Yueqing Y Brasier Allan R AR

Journal of proteomics 20160725

<h4>Unlabelled</h4>The airway epithelium is a semi-impermeable barrier whose disruption by growth factor reprogramming is associated with chronic airway diseases of humans. Transforming growth factor beta (TGFβ)-induced epithelial mesenchymal transition (EMT) plays important roles in airway remodeling characteristic of idiopathic lung fibrosis, asthma and chronic obstructive pulmonary disease (COPD). Inflammation of the airways leads to airway injury and tumor necrosis factor alpha (TNFα) plays ...[more]

PMID: 27461979

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