Dataset Information

Fibronectin-binding integrins alpha-v-beta6 and alpha9beta1 drive TGF-beta independent directional migration of head and neck carcinoma collectives through fibroblast-derived matrix

ABSTRACT: For a tumor to develop and spread, the growth-repressive environment of the host tissue must undergo profound changes. These include dramatic modifications in the molecular composition and architecture of the extracellular matrix (ECM) and altered integrin expression in cancer cells to allow productive interactions. An overwhelming proportion of histopathologically invasive carcinomas, including HNSCC, retain an epithelial phenotype at invading tumor fronts. Local adhesion-dependent signals at the tumor-stroma interface can govern the different modes that tumor cells adopt to invade surrounding stroma. Defining the nature and organization of the tumor ECM and the adhesive interactions that promote cancer cell invasion is of utmost importance for tailoring effective therapies to control locoregional expansion and metastatic dissemination.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture, Fibroblast

DISEASE(S): Neck Carcinoma

SUBMITTER: Luc Camoin

LAB HEAD: Luc Camoin

PROVIDER: PXD003457 | Pride | 2016-12-24

REPOSITORIES: Pride

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Publications

Fibronectin-guided migration of carcinoma collectives.

Gopal Sandeep S Veracini Laurence L Grall Dominique D Butori Catherine C Schaub Sébastien S Audebert Stéphane S Camoin Luc L Baudelet Emilie E Radwanska Agata A Beghelli-de la Forest Divonne Stéphanie S Violette Shelia M SM Weinreb Paul H PH Rekima Samah S Ilie Marius M Sudaka Anne A Hofman Paul P Van Obberghen-Schilling Ellen E

Nature communications 20170119

Functional interplay between tumour cells and their neoplastic extracellular matrix plays a decisive role in malignant progression of carcinomas. Here we provide a comprehensive data set of the human HNSCC-associated fibroblast matrisome. Although much attention has been paid to the deposit of collagen, we identify oncofetal fibronectin (FN) as a major and obligate component of the matrix assembled by stromal fibroblasts from head and neck squamous cell carcinomas (HNSCC). FN overexpression in t ...[more]

PMID: 28102238

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