Proteomics

Dataset Information

0

Mouse_T1D_microbiota - Clostridial Butyrate Biosynthesis Enzymes Are Significantly Depleted in the Gut Microbiota of Nonobese Diabetic Mice


ABSTRACT: A metaproteomic approach was exploited to investigate microbiota protein expression in feces from Eα16 and NOD mice at 10 weeks of age (n=6 vs 6 mice)

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Gut Metagenome Mus Musculus (mouse)

TISSUE(S): Feces

DISEASE(S): Type 1 Diabetes Mellitus

SUBMITTER: Alessandro Tanca  

LAB HEAD: Sergio Uzzau

PROVIDER: PXD003616 | Pride | 2018-10-15

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
Ea16_W10_C2_M900_S4.msf Msf
Ea16_W10_C2_M900_S4.pdResult Other
Ea16_W10_C2_M900_S4.raw Raw
Ea16_W10_C2_M900_S4_host.msf Msf
Ea16_W10_C2_M901_S3.msf Msf
Items per page:
1 - 5 of 51
altmetric image

Publications

Clostridial Butyrate Biosynthesis Enzymes Are Significantly Depleted in the Gut Microbiota of Nonobese Diabetic Mice.

Tanca Alessandro A   Palomba Antonio A   Fraumene Cristina C   Manghina Valeria V   Silverman Michael M   Uzzau Sergio S  

mSphere 20181024 5


Increasing evidence suggests that the intestinal microbiota is involved in the pathogenesis of type 1 diabetes (T1D). Here we sought to determine which gut microbial taxa and functions vary between nonobese diabetic (NOD) mice and genetically modified NOD mice protected from T1D (Eα16/NOD) at 10 weeks of age in the time window between insulitis development and T1D onset. The gut microbiota of NOD mice were investigated by analyzing stool samples with a metaproteogenomic approach, comprising both  ...[more]

Similar Datasets

2017-03-31 | PXD004911 | Pride
2016-10-10 | PXD004039 | Pride
2017-07-19 | PXD005780 | Pride
2017-02-22 | PXD004524 | Pride
2023-05-16 | PXD030708 | Pride
2013-11-06 | E-GEOD-52030 | biostudies-arrayexpress
2013-02-09 | E-GEOD-43360 | biostudies-arrayexpress
2013-11-04 | E-GEOD-50544 | biostudies-arrayexpress
2013-11-05 | E-MTAB-1948 | biostudies-arrayexpress
2016-07-11 | PXD003882 | Pride