Proteomics

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Inflammatory signaling in human Tuberculosis granulomas is spatially organized

ABSTRACT: Granulomas are the pathological hallmark of tuberculosis (TB). However, their function and mechanisms of formation remain poorly understood. To understand the role of granulomas in TB, we analyzed the proteomes of granulomas from TB patients in an unbiased fashion. Using laser capture microdissection and mass spectrometry , we generated detailed molecular maps of human granulomas. We found that the centers of granulomas possess a pro-inflammatory environment characterized by anti-microbial peptides, ROS and pro-inflammatory eicosanoids. Conversely, the tissue surrounding the caseum possesses a comparatively anti-inflammatory signature.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Lung

DISEASE(S): Pulmonary Tuberculosis

SUBMITTER: Mario Oroshi  

LAB HEAD: Matthias Mann

PROVIDER: PXD003646 | Pride | 2016-02-26

REPOSITORIES: Pride

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20120804_EXQ1_KiSh_SA_Collab_TB_Ingel_1.raw Raw
20120804_EXQ1_KiSh_SA_Collab_TB_Ingel_2.raw Raw
20120804_EXQ1_KiSh_SA_Collab_TB_Ingel_3.raw Raw
20120804_EXQ1_KiSh_SA_Collab_TB_Ingel_4.raw Raw
20120804_EXQ1_KiSh_SA_Collab_TB_Ingel_5.raw Raw
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Publications

Granulomas are the pathological hallmark of tuberculosis (TB). However, their function and mechanisms of formation remain poorly understood. To understand the role of granulomas in TB, we analyzed the proteomes of granulomas from subjects with tuberculosis in an unbiased manner. Using laser-capture microdissection, mass spectrometry and confocal microscopy, we generated detailed molecular maps of human granulomas. We found that the centers of granulomas have a pro-inflammatory environment that i  ...[more]

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