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Mouse retinal tissue study in VEGF-induced hyperpermeability.

ABSTRACT: The goal of the project is to identify novel therapeutic targets for retinal vascular hyperpermeability. Three condition (Control, VEGF, and Anti-VEGF) sample of mouse retinal tissues were extensively characterized by global proteome profiling.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Retina

SUBMITTER: Dong-Gi Mun

LAB HEAD: Sang-Won Lee

PROVIDER: PXD003656 | Pride | 2016-03-22

REPOSITORIES: Pride

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			Action	DRS
	FN01_Mouseretina_set1_180min_10ug_C1_100715.raw	Raw
	FN01_Mouseretina_set1_180min_10ug_C1_100715_PEMMR.mgf	Mgf
	FN01_Mouseretina_set1_180min_10ug_C1_100715_PEMMR.mzid.gz	Mzid
	FN01_Mouseretina_set1_180min_10ug_C1_100715_PEMMR.pride.mgf.gz	Mgf
	FN01_Mouseretina_set1_180min_10ug_C1_100715_PEMMR.pride.mztab.gz	Mztab

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Publications

Quantitative Proteomics Reveals β2 Integrin-mediated Cytoskeletal Rearrangement in Vascular Endothelial Growth Factor (VEGF)-induced Retinal Vascular Hyperpermeability.

Jo Dong Hyun DH Bae Jingi J Chae Sehyun S Kim Jin Hyoung JH Han Jong-Hee JH Hwang Daehee D Lee Sang-Won SW Kim Jeong Hun JH

Molecular & cellular proteomics : MCP 20160311 5

Retinal vascular hyperpermeability causes macular edema, leading to visual deterioration in retinal diseases such as diabetic retinopathy and retinal vascular occlusion. Dysregulation of junction integrity between endothelial cells by vascular endothelial growth factor (VEGF) was shown to cause retinal vascular hyperpermeability. Accordingly, anti-VEGF agents have been used to treat retinal vascular hyperpermeability. However, they can confer potential toxicity through their deleterious effects ...[more]

PMID: 26969716

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Expression analysis of mouse retinas after treatment with VEGF-A or Dll4-Fc.

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