Dataset Information

Distinct Combinatorial Cascade of Events Generated by ECM Proteolysis Dictates Cell Behavior, part 2

ABSTRACT: It is well established that the expression profiles of multiple and possibly redundant matrix remodeling proteases (e.g. collagenases) strongly differentiates in disease and development. Although enzymatic redundancy might be inferred from their close similarity in structure, their in-vivo activity can lead to extremely diverse tissue-remodeling outcomes. We observed that proteolysis of collagen, generated uniquely by individual homologous proteases, leads to a specific cascade of combinatorial events, which eventually affects overall extracellular matrix (ECM) topography, visco-elastic properties

OTHER RELATED OMICS DATASETS IN: PRJNA316930

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Tail

SUBMITTER: Yishai Levin

LAB HEAD: Irit Sagi

PROVIDER: PXD003796 | Pride | 2016-09-27

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	MMP1_1-12-281211_Merge.sf3	Other
	Sagi_281211_Inna_gel_MMP1_all_12_120101110948.RAW	Raw
	Sagi_281211_Inna_gel_MMP1_all_13.RAW	Raw
	Sagi_281211_Inna_gel_MMP1_all_14.RAW	Raw
	Sagi_311211_Inna_gel_MMP2_all_13.RAW	Raw

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Publications

Distinct biological events generated by ECM proteolysis by two homologous collagenases.

Solomonov Inna I Zehorai Eldar E Talmi-Frank Dalit D Wolf Sharon G SG Shainskaya Alla A Zhuravlev Alina A Kartvelishvily Elena E Visse Robert R Levin Yishai Y Kampf Nir N Jaitin Diego Adhemar DA David Eyal E Amit Ido I Nagase Hideaki H Sagi Irit I

Proceedings of the National Academy of Sciences of the United States of America 20160914 39

It is well established that the expression profiles of multiple and possibly redundant matrix-remodeling proteases (e.g., collagenases) differ strongly in health, disease, and development. Although enzymatic redundancy might be inferred from their close similarity in structure, their in vivo activity can lead to extremely diverse tissue-remodeling outcomes. We observed that proteolysis of collagen-rich natural extracellular matrix (ECM), performed uniquely by individual homologous proteases, lea ...[more]

PMID: 27630193

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