Proteomics

Dataset Information

0

TIA1 interactome from mouse cortex


ABSTRACT: The purpose of this experiment was to characterize the network of proteins that interact with TIA1, and to investigate whether tau exerts control over TIA1 protein interactions, TIA1 was immunoprecipitated from cortical brain tissue of 10 month-old WT (C57BL/6J), tau-/- and TIA1-/- mice. The specificity of the TIA1 IP was verified by immunoblotting with anti-TIA1 antibody (Fig. 3A), and the resulting TIA1 proteome was examined by mass spectrometry.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain, Cns Neuron (sensu Vertebrata)

DISEASE(S): Disease Free

SUBMITTER: Benjamin Wolozin  

LAB HEAD: Benjamin Wolozin

PROVIDER: PXD003922 | Pride | 2018-10-26

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
012915BW1-01.mzid.gz Mzid
012915BW1-01.mzid_012915BW1-01.MGF Mzid
012915BW1-01.mzid_012915BW1-01.pride.mgf.gz Mzid
012915BW1-01.pride.mztab.gz Mztab
012915BW1.raw Raw
Items per page:
1 - 5 of 35
altmetric image

Publications


Dendritic mislocalization of microtubule associated protein tau is a hallmark of tauopathies, but the role of dendritic tau is unknown. We now report that tau interacts with the RNA-binding protein (RBP) TIA1 in brain tissue, and we present the brain-protein interactome network for TIA1. Analysis of the TIA1 interactome in brain tissue from wild-type (WT) and tau knockout mice demonstrates that tau is required for normal interactions of TIA1 with proteins linked to RNA metabolism, including ribo  ...[more]

Similar Datasets

2020-01-30 | PXD015432 | Pride
2024-06-18 | PXD046645 | Pride
2023-02-03 | PXD033965 | Pride
2019-01-09 | PXD009294 | Pride
2024-07-03 | PXD044959 | Pride
2020-02-14 | PXD016862 | Pride
2024-06-18 | PXD034527 | Pride
2015-05-15 | PXD001353 | Pride
2021-07-12 | PXD026790 | Pride
2019-05-17 | PXD013341 | Pride