Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Brain
SUBMITTER: Duc Duong
LAB HEAD: Nicholas Seyfried
PROVIDER: PXD016862 | Pride | 2020-02-14
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
ad1_a.msf | Msf | |||
ad1_a.pdResult | Other | |||
ad1_a.raw | Raw | |||
ad1_b.msf | Msf | |||
ad1_b.pdResult | Other |
Items per page: 5 1 - 5 of 15 |
Arakhamia Tamta T Lee Christina E CE Carlomagno Yari Y Duong Duc M DM Kundinger Sean R SR Wang Kevin K Williams Dewight D DeTure Michael M Dickson Dennis W DW Cook Casey N CN Seyfried Nicholas T NT Petrucelli Leonard L Fitzpatrick Anthony W P AWP
Cell 20200206 4
Tau aggregation into insoluble filaments is the defining pathological hallmark of tauopathies. However, it is not known what controls the formation and templated seeding of strain-specific structures associated with individual tauopathies. Here, we use cryo-electron microscopy (cryo-EM) to determine the structures of tau filaments from corticobasal degeneration (CBD) human brain tissue. Cryo-EM and mass spectrometry of tau filaments from CBD reveal that this conformer is heavily decorated with p ...[more]