Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion ETD
ORGANISM(S): Staphylococcus Aureus
SUBMITTER: Egor Vorontsov
LAB HEAD: Dan I. Andersson
PROVIDER: PXD004036 | Pride | 2016-09-26
REPOSITORIES: Pride
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Kubicek-Sutherland Jessica Z JZ Lofton Hava H Vestergaard Martin M Hjort Karin K Ingmer Hanne H Andersson Dan I DI
The Journal of antimicrobial chemotherapy 20160920 1
<h4>Background</h4>The clinical development of antimicrobial peptides (AMPs) is currently under evaluation to combat the rapid increase in MDR bacterial pathogens. However, many AMPs closely resemble components of the human innate immune system and the ramifications of prolonged bacterial exposure to AMPs are not fully understood.<h4>Objectives</h4>We show that in vitro serial passage of a clinical USA300 MRSA strain in a host-mimicking environment containing host-derived AMPs results in the sel ...[more]