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Human omentum from patients with High-grade serous ovarian cancer

ABSTRACT: High-resolution multi-layered profiling of human ovarian cancer metastases.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Primary Cell, Epithelial Cell

DISEASE(S): Malignant Neoplasm Of Ovary

SUBMITTER: Vinothini Rajeeve

LAB HEAD: Pedro R Cutillas

PROVIDER: PXD004060 | Pride | 2018-02-20

REPOSITORIES: Pride

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			Action	DRS
	F001235.dat	Other
	F001236.dat	Other
	F001237.dat	Other
	F001238.dat	Other
	F001239.dat	Other

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Publications

Deconstruction of a Metastatic Tumor Microenvironment Reveals a Common Matrix Response in Human Cancers.

Pearce Oliver M T OMT Delaine-Smith Robin M RM Maniati Eleni E Nichols Sam S Wang Jun J Böhm Steffen S Rajeeve Vinothini V Ullah Dayem D Chakravarty Probir P Jones Roanne R RR Montfort Anne A Dowe Tom T Gribben John J Jones J Louise JL Kocher Hemant M HM Serody Jonathan S JS Vincent Benjamin G BG Connelly John J Brenton James D JD Chelala Claude C Cutillas Pedro R PR Lockley Michelle M Bessant Conrad C Knight Martin M MM Balkwill Frances R FR

Cancer discovery 20171201 3

We have profiled, for the first time, an evolving human metastatic microenvironment by measuring gene expression, matrisome proteomics, cytokine and chemokine levels, cellularity, extracellular matrix organization, and biomechanical properties, all on the same sample. Using biopsies of high-grade serous ovarian cancer metastases that ranged from minimal to extensive disease, we show how nonmalignant cell densities and cytokine networks evolve with disease progression. Multivariate integration of ...[more]

PMID: 29196464

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