Proteomics

Dataset Information

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P falciparum Pf377 protein complex in gametocytes


ABSTRACT: The identification of Pf377 interacting proteins in the osmiophilic bodies in P. falciparum gametocytes. In a comparative proteomics approach, immunopurified Pfg377 complexes were obtained in wild type and Osmiophilic Body -depleted gametocytes (Pf377 knock out gametocytes) and were analyzed by LC-MS/MS to identify Pfg377 interaction partners in wt gametocytes as candidate for OB associated proteins.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Plasmodium Falciparum (isolate 3d7)

TISSUE(S): Blood Cell, Blood

DISEASE(S): Plasmodium Falciparum Malaria

SUBMITTER: Edwin Lasonder  

LAB HEAD: Edwin Lasonder

PROVIDER: PXD004088 | Pride | 2018-10-26

REPOSITORIES: pride

Dataset's files

Source:
Action DRS
20131010EL02.raw Raw
20131016EL03.raw Raw
20131016EL04.raw Raw
20131016EL06.raw Raw
20131016EL09.raw Raw
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Publications

Comparative Proteomics and Functional Analysis Reveal a Role of Plasmodium falciparum Osmiophilic Bodies in Malaria Parasite Transmission.

Suárez-Cortés Pablo P   Sharma Vikram V   Bertuccini Lucia L   Costa Giulia G   Bannerman Naa-Lamiley NL   Sannella Anna Rosa AR   Sannella Anna Rosa AR   Williamson Kim K   Klemba Michael M   Levashina Elena A EA   Lasonder Edwin E   Alano Pietro P  

Molecular & cellular proteomics : MCP 20160718 10


An essential step in the transmission of the malaria parasite to the Anopheles vector is the transformation of the mature gametocytes into gametes in the mosquito gut, where they egress from the erythrocytes and mate to produce a zygote, which matures into a motile ookinete. Osmiophilic bodies are electron dense secretory organelles of the female gametocytes which discharge their contents during gamete formation, suggestive of a role in gamete egress. Only one protein with no functional annotati  ...[more]

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