Proteomics

Dataset Information

0

Spike-in SILAC MS of C. elegans CPEB homolog mutants.


ABSTRACT: Comparative proteomic study between C. elegans wild-type N2 and CPEB homolog mutants: fog-1, cpb-2, and cpb-3.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Caenorhabditis Elegans

TISSUE(S): Whole Body

SUBMITTER: Kapil Dev Singh  

LAB HEAD: Michael O. Hengartner

PROVIDER: PXD004104 | Pride | 2017-08-02

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
MS_MethodSummary.zip Other
Singh_etal_201605_N2_L3_RAW.zip Other
Singh_etal_201605_N2_L3_SEARCH.zip Other
Singh_etal_201605_N2_L4_RAW.zip Other
Singh_etal_201605_N2_L4_SEARCH.zip Other
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Publications

Differential regulation of germ line apoptosis and germ cell differentiation by CPEB family members in C. elegans.

Singh Kapil Dev KD   Zheng Xue X   Milstein Stuart S   Keller Martin M   Roschitzki Bernd B   Grossmann Jonas J   Hengartner Michael O MO  

PloS one 20170731 7


Cytoplasmic polyadenylation element binding (CPEB) proteins are evolutionary conserved RNA-binding proteins that control mRNA polyadenylation and translation. Orthologs in humans and other vertebrates are mainly involved in oogenesis. This is also the case for the C. elegans CPEB family member CPB-3, whereas two further CPEB proteins (CPB-1 and FOG-1) are involved in spermatogenesis. Here we describe the characterisation of a new missense allele of cpb-3 and show that loss of cpb-3 function lead  ...[more]

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