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RNA-seq analysis of C. elegans CPEB homolog mutants.

ABSTRACT: Comparative transcriptomics study between C. elegans wild-type N2 and CPEB homolog mutants: fog-1, cpb-2, and cpb-3.

INSTRUMENT(S): Illumina HiSeq 2500

ORGANISM(S): Caenorhabditis elegans

SUBMITTER: Kapil Dev Singh

PROVIDER: E-MTAB-4720 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Differential regulation of germ line apoptosis and germ cell differentiation by CPEB family members in C. elegans.

Singh Kapil Dev KD Zheng Xue X Milstein Stuart S Keller Martin M Roschitzki Bernd B Grossmann Jonas J Hengartner Michael O MO

PloS one 20170731 7

Cytoplasmic polyadenylation element binding (CPEB) proteins are evolutionary conserved RNA-binding proteins that control mRNA polyadenylation and translation. Orthologs in humans and other vertebrates are mainly involved in oogenesis. This is also the case for the C. elegans CPEB family member CPB-3, whereas two further CPEB proteins (CPB-1 and FOG-1) are involved in spermatogenesis. Here we describe the characterisation of a new missense allele of cpb-3 and show that loss of cpb-3 function lead ...[more]

PMID: 28759574

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Project description:Comparative proteomic study between C. elegans wild-type N2 and CPEB homolog mutants: fog-1, cpb-2, and cpb-3.

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