Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: Stephanie Wilhelm
LAB HEAD: Bernhard Kuster
PROVIDER: PXD004112 | Pride | 2016-12-23
REPOSITORIES: Pride
Action | DRS | |||
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ASP-3026.zip | Other | |||
ASP-3026_txt.zip | Other | |||
Alisertib.zip | Other | |||
Alisertib_txt.zip | Other | |||
BMS-690514.zip | Other |
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ACS chemical biology 20161107 12
The receptor tyrosine kinase EPHA2 (Ephrin type-A receptor 2) plays important roles in oncogenesis, metastasis, and treatment resistance, yet therapeutic targeting, drug discovery, or investigation of EPHA2 biology is hampered by the lack of appropriate inhibitors and structural information. Here, we used chemical proteomics to survey 235 clinical kinase inhibitors for their kinase selectivity and identified 24 drugs with submicromolar affinities for EPHA2. NMR-based conformational dynamics toge ...[more]