Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos, Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Maria Reinecke
LAB HEAD: Prof. Dr. Bernhard Kuster
PROVIDER: PXD031880 | Pride | 2024-05-23
REPOSITORIES: Pride
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Chemistry (Weinheim an der Bergstrasse, Germany) 20230322 23
The ephrin type-A receptor 2 (EPHA2) kinase belongs to the largest family of receptor tyrosine kinases. There are several indications of an involvement of EPHA2 in the development of infectious diseases and cancer. Despite pharmacological potential, EPHA2 is an under-examined target protein. In this study, we synthesized a series of derivatives of the inhibitor NVP-BHG712 and triazine-based compounds. These compounds were evaluated to determine their potential as kinase inhibitors of EPHA2, incl ...[more]