Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Brain
SUBMITTER: Yohann Couté
LAB HEAD: Bruley
PROVIDER: PXD004215 | Pride | 2017-07-19
REPOSITORIES: Pride
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Alfieri Annalisa A Sorokina Oksana O Adrait Annie A Angelini Costanza C Russo Isabella I Morellato Alessandro A Matteoli Michela M Menna Elisabetta E Boeri Erba Elisabetta E McLean Colin C Armstrong J Douglas JD Ala Ugo U Buxbaum Joseph D JD Brusco Alfredo A Couté Yohann Y De Rubeis Silvia S Turco Emilia E Defilippi Paola P
Frontiers in molecular neuroscience 20170630
Altered synaptic function has been associated with neurological and psychiatric conditions including intellectual disability, schizophrenia and autism spectrum disorder (ASD). Amongst the recently discovered synaptic proteins is p140Cap, an adaptor that localizes at dendritic spines and regulates their maturation and physiology. We recently showed that p140Cap knockout mice have cognitive deficits, impaired long-term potentiation (LTP) and long-term depression (LTD), and immature, filopodia-like ...[more]