Proteomics

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P140Cap Interactome - Synaptic Interactome Mining Reveals p140Cap as a New Hub for PSD Proteins Involved in Psychiatric and Neurological Disorders

ABSTRACT: p140Cap is an adapter protein that is highly expressed in the brain. In particular, p140Cap localizes at dendritic spines where it contributes to the regulation of spine shape and maturation. We recently described that p140Cap knock-out mice present cognitive deficits, impaired long-term potentiation and long-term depression, and immature filopodia-like dendritic spines, indicating that p140Cap is relevant for synaptic plasticity. Although a few p140Cap interacting proteins have been identified in the brain, a comprehensive view of its molecular partners remains largely unknown. Thus, we performed a mass spectrometry-based proteomic analysis of the p140Cap interactome.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain

SUBMITTER: Yohann Couté  

LAB HEAD: Bruley

PROVIDER: PXD004215 | Pride | 2017-07-19

REPOSITORIES: pride

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Altered synaptic function has been associated with neurological and psychiatric conditions including intellectual disability, schizophrenia and autism spectrum disorder (ASD). Amongst the recently discovered synaptic proteins is p140Cap, an adaptor that localizes at dendritic spines and regulates their maturation and physiology. We recently showed that p140Cap knockout mice have cognitive deficits, impaired long-term potentiation (LTP) and long-term depression (LTD), and immature, filopodia-like  ...[more]

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