Ontology highlight
ABSTRACT:
INSTRUMENT(S): Synapt MS
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Brain, Synapse
DISEASE(S): Alzheimer's Disease
SUBMITTER: Reddy Peera Kommaddi
LAB HEAD: Reddy Peera Kommaddi
PROVIDER: PXD050802 | Pride | 2024-10-17
REPOSITORIES: Pride
Action | DRS | |||
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APPPS1_1.zip | Other | |||
APPPS1_1_DAT.zip | Other | |||
APPPS1_2.zip | Other | |||
APPPS1_2_DAT.zip | Other | |||
APPPS1_3.dat | Other |
Items per page: 5 1 - 5 of 12 |
P A Haseena H Basavaraju Nimisha N Chandran Mahesh M Jaleel Abdul A Bennett David A DA Kommaddi Reddy Peera RP
Alzheimer's research & therapy 20240907 1
<h4>Background</h4>Synaptic dysfunction, characterized by synapse loss and structural alterations, emerges as a prominent correlate of cognitive decline in Alzheimer's disease (AD). Actin cytoskeleton, which serves as the structural backbone of synaptic architecture, is observed to be lost from synapses in AD. Actin cytoskeleton loss compromises synaptic integrity, affecting glutamatergic receptor levels, neurotransmission, and synaptic strength. Understanding these molecular changes is crucial ...[more]