Dataset Information

Human bladder cancer and colon cancer quatitative MS/MS

ABSTRACT: We analyzed a set of 40 independently collected tumor tissue/control samples using a label-free quantitation single pass LC-MS/MS approach. In this set, 10 samples originated from a colon tumor (i.e. AC) and 10 from control non-malignant tissue samples (NCA), as well as 10 from BC samples and 10 from control bladder tissue (NCB) samples.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Colon, Urinary Bladder

DISEASE(S): Colon Cancer,Disease Free,Urinary Bladder Cancer

SUBMITTER: Michał Kistowski

LAB HEAD: Michał Dadlez

PROVIDER: PXD004249 | Pride | 2016-12-14

REPOSITORIES: Pride

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Publications

A Strong Neutrophil Elastase Proteolytic Fingerprint Marks the Carcinoma Tumor Proteome.

Kistowski Michał M Dębski Janusz J Karczmarski Jakub J Paziewska Agnieszka A Olędzki Jacek J Mikula Michał M Ostrowski Jerzy J Dadlez Michał M

Molecular & cellular proteomics : MCP 20161207 2

Proteolytic cascades are deeply involved in critical stages of cancer progression. During the course of peptide-wise analysis of shotgun proteomic data sets representative of colon adenocarcinoma (AC) and ulcerative colitis (UC), we detected a cancer-specific proteolytic fingerprint composed of a set of numerous protein fragments cleaved C-terminally to V, I, A, T, or C residues, significantly overrepresented in AC. A peptide set linked by a common VIATC cleavage consensus was the only prominent ...[more]

PMID: 27927741

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