Dataset Information

Proteomic profiling of glioblastoma tumour tissue

ABSTRACT: Using HiRIEF LC-MS/MS, we analysed 10 GBM tumour tissue samples ran in one TMT10 set. The set consisted of 7 primary tumours and 3 non-matched recurrent tumours. One primary tumour was highly necrotic.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Malignant Cell, Brain

DISEASE(S): Glioblastoma,Brain Cancer,Idh-wildtype Glioblastoma

SUBMITTER: Haris Babačić

LAB HEAD: Janne Lehtiö

PROVIDER: PXD027341 | Pride | 2022-12-23

REPOSITORIES: Pride

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			Action	DRS
	20200923_GBM_tumour_tissue__TMT10plex_HiRIEF_3-10_fr01.raw	Raw
	20200923_GBM_tumour_tissue__TMT10plex_HiRIEF_3-10_fr02.raw	Raw
	20200923_GBM_tumour_tissue__TMT10plex_HiRIEF_3-10_fr03.raw	Raw
	20200923_GBM_tumour_tissue__TMT10plex_HiRIEF_3-10_fr04.raw	Raw
	20200923_GBM_tumour_tissue__TMT10plex_HiRIEF_3-10_fr05.raw	Raw

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Publications

Glioblastoma stem cells express non-canonical proteins and exclusive mesenchymal-like or non-mesenchymal-like protein signatures.

Babačić Haris H Galardi Silvia S Umer Husen M HM Hellström Mats M Uhrbom Lene L Maturi Nagaprathyusha N Cardinali Deborah D Pellegatta Serena S Michienzi Alessandro A Trevisi Gianluca G Mangiola Annunziato A Lehtiö Janne J Ciafrè Silvia Anna SA Pernemalm Maria M

Molecular oncology 20230116 2

Glioblastoma (GBM) cancer stem cells (GSCs) contribute to GBM's origin, recurrence, and resistance to treatment. However, the understanding of how mRNA expression patterns of GBM subtypes are reflected at global proteome level in GSCs is limited. To characterize protein expression in GSCs, we performed in-depth proteogenomic analysis of patient-derived GSCs by RNA-sequencing and mass-spectrometry. We quantified > 10 000 proteins in two independent GSC panels and propose a GSC-associated proteomi ...[more]

PMID: 36495079

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