Proteomics

Dataset Information

0

SgK269 Interactome - Homo- and Heterotypic Association Regulates Signalling by the SgK269/PEAK1 and SgK223 Pseudokinases


ABSTRACT: Anti Flag IP of Flag-SgK269 and control IP from MCF10A EcoR cells.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Cell Culture

DISEASE(S): Breast Cancer

SUBMITTER: Brock Conley  

LAB HEAD: Professor Roger Daly

PROVIDER: PXD004250 | Pride | 2016-08-24

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
MaxQuantOutput.tar.gz Other
ZC20140815_DSR_1.raw Raw
ZC20140815_DSR_2.raw Raw
ZC20140815_DSR_3.raw Raw
ZC20140815_SGK_1.raw Raw
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Publications

Homo- and Heterotypic Association Regulates Signaling by the SgK269/PEAK1 and SgK223 Pseudokinases.

Liu Ling L   Phua Yu Wei YW   Lee Rachel S RS   Ma Xiuquan X   Jenkins Yiping Y   Novy Karel K   Humphrey Emily S ES   Chan Howard H   Shearer Robert R   Ong Poh Chee PC   Dai Weiwen W   Saunders Darren N DN   Lucet Isabelle S IS   Daly Roger J RJ  

The Journal of biological chemistry 20160816 41


SgK269/PEAK1 is a pseudokinase and scaffolding protein that plays a critical role in regulating growth factor receptor signal output and is implicated in the progression of several cancers, including those of the breast, colon, and pancreas. SgK269 is structurally related to SgK223, a human pseudokinase that also functions as a scaffold but recruits a distinct repertoire of signaling proteins compared with SgK269. Structural similarities between SgK269 and SgK223 include a predicted α-helical re  ...[more]

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