Proteomics

Dataset Information

0

Proline hydroxylation of ChREBP


ABSTRACT: This project investigated proline hydroxylation of ChREBP. Proline hydroxylation was investigated in flag-IP enriched protein extracts from ChREBP-flag overexpressing HEK293 cells (A) and in ChREBP-IP enriched mouse liver protein (male, C57BL6/J) (B).

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Liver

SUBMITTER: Michael Schupp  

LAB HEAD: Michael Schupp

PROVIDER: PXD019137 | Pride | 2020-10-19

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
HEKsampleMascotSearchResultsQ99MZ3.htm Other
MS619_HS447_3_HEK293_A.raw Raw
MS683_HS473_D_mouse_liver_B.raw Raw
mouseliverMascotSearchResultsQ99MZ3.htm Other
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Publications


Cellular energy demands are met by uptake and metabolism of nutrients like glucose. The principal transcriptional regulator for adapting glycolytic flux and downstream pathways like <i>de novo</i> lipogenesis to glucose availability in many cell types is carbohydrate response element-binding protein (ChREBP). ChREBP is activated by glucose metabolites and post-translational modifications, inducing nuclear accumulation and regulation of target genes. Here we report that ChREBP is modified by prol  ...[more]

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