Proteomics,Multiomics

Dataset Information

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Phosphoproteomics of PDT treated SK-ChA-1 cells


ABSTRACT: (Phospho)proteomic study of the cell survival pathways induced by ZnPC-encapsulating PEGylated cationic liposomes (ZPCLs) in SK-ChA-1 cells.

OTHER RELATED OMICS DATASETS IN: GSE84758PRJNA331051PRJNA331048PRJNA331050

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Simone Lemeer  

LAB HEAD: Simone Lemeer

PROVIDER: PXD004320 | Pride | 2018-10-27

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
OR10_20150601_SC_CT2_01.raw Raw
OR10_20150601_SC_CT3_02.raw Raw
OR10_20150601_SC_CT4_01.raw Raw
OR10_20150601_SC_DT2_01.raw Raw
OR10_20150601_SC_DT3_01.raw Raw
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Publications

Multi-OMIC profiling of survival and metabolic signaling networks in cells subjected to photodynamic therapy.

Weijer Ruud R   Clavier Séverine S   Zaal Esther A EA   Pijls Maud M E MM   van Kooten Robert T RT   Vermaas Klaas K   Leen René R   Jongejan Aldo A   Moerland Perry D PD   van Kampen Antoine H C AH   van Kuilenburg André B P AB   Berkers Celia R CR   Lemeer Simone S   Heger Michal M  

Cellular and molecular life sciences : CMLS 20161101 6


Photodynamic therapy (PDT) is an established palliative treatment for perihilar cholangiocarcinoma that is clinically promising. However, tumors tend to regrow after PDT, which may result from the PDT-induced activation of survival pathways in sublethally afflicted tumor cells. In this study, tumor-comprising cells (i.e., vascular endothelial cells, macrophages, perihilar cholangiocarcinoma cells, and EGFR-overexpressing epidermoid cancer cells) were treated with the photosensitizer zinc phthalo  ...[more]

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