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Transcription factor-SNP interactome for colorectal cancer risk loci

ABSTRACT: A core task to understand the consequences of non-coding single nucleotide polymorphisms (SNP) is to identify their genotype specific binding of transcription factor (TF). Here, we generate a large-scale TF-SNP interaction map for a selection of 116 colorectal cancer (CRC) risk loci and validated TF binding to 10 putatively functional SNPs. Our data further revealed TF binding complexity adjacent to the 116 risk loci, adding an additional layer of understanding to regulatory networks associated with CRC relevant loci.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Colon

DISEASE(S): Colon Cancer

SUBMITTER: Ning Qing Liu

LAB HEAD: Ning Qing Liu

PROVIDER: PXD004435 | Pride | 2017-02-23

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	116_FPPD_LFQ_analysis_txt.7z	Other
	116_SNPs_FPPD_Dimethyl_analysis_txt.7z	Other
	20140307_Q1_SA_NiQi_LOVO_FASP_SAX_PH11.raw	Raw
	20140307_Q1_SA_NiQi_LOVO_FASP_SAX_PH3.raw	Raw
	20140307_Q1_SA_NiQi_LOVO_FASP_SAX_PH4.raw	Raw

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