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CSF comparison MS and controls

ABSTRACT: Comparison of the global CSF proteome between multiple sclerosis and neurological controls

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cerebrospinal Fluid

SUBMITTER: Ann Cathrine Kroksveen

LAB HEAD: Frode S. Berven

PROVIDER: PXD004572 | Pride | 2016-10-13

REPOSITORIES: Pride

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			Action	DRS
	MM25.mgf	Mgf
	MM25.raw	Raw
	MM26.mgf	Mgf
	MM26.raw	Raw
	MM27.mgf	Mgf

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Publications

In-Depth Cerebrospinal Fluid Quantitative Proteome and Deglycoproteome Analysis: Presenting a Comprehensive Picture of Pathways and Processes Affected by Multiple Sclerosis.

Kroksveen Ann Cathrine AC Guldbrandsen Astrid A Vaudel Marc M Lereim Ragnhild Reehorst RR Barsnes Harald H Myhr Kjell-Morten KM Torkildsen Øivind Ø Berven Frode S FS

Journal of proteome research 20161026 1

In the current study, we conducted a quantitative in-depth proteome and deglycoproteome analysis of cerebrospinal fluid (CSF) from relapsing-remitting multiple sclerosis (RRMS) and neurological controls using mass spectrometry and pathway analysis. More than 2000 proteins and 1700 deglycopeptides were quantified, with 484 proteins and 180 deglycopeptides significantly changed between pools of RRMS and pools of controls. Approximately 300 of the significantly changed proteins were assigned to var ...[more]

PMID: 27728768

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