Proteomics

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Multiple sclerosis biomarker discovery in cerebrospinal fluid using glycopeptide enrichment, TMT labeling and LC-MS/MS

ABSTRACT: Multiple sclerosis biomarker discovery in pooled cerebrospinal fluid (CSF) using glycopeptide enrichment, TMT labeling and LC-MS/MS. Comparing 3 pools of CSF from relapsing-remitting MS (RRMS) patients to 3 pools of CSF from patients with other neurological diseases (OND). To reveal protein groups and networks affected by MS and to look at correlation between a glyco and a global approach.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cerebrospinal Fluid

DISEASE(S): Multiple Sclerosis

SUBMITTER: Astrid Guldbrandsen  

LAB HEAD: Frode S. Berven

PROVIDER: PXD004540 | Pride | 2016-10-13

REPOSITORIES: Pride

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20150309_TMT_SPEG_50cm_90min.mgf Mgf
20150309_TMT_SPEG_50cm_90min.pride.mgf.gz Mgf
20150309_TMT_SPEG_50cm_90min.raw Raw
20150311_CSF_TMT_SPEG_MM_1.mgf Mgf
20150311_CSF_TMT_SPEG_MM_1.pride.mgf.gz Mgf
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Publications

In-Depth Cerebrospinal Fluid Quantitative Proteome and Deglycoproteome Analysis: Presenting a Comprehensive Picture of Pathways and Processes Affected by Multiple Sclerosis.

Kroksveen Ann Cathrine AC   Guldbrandsen Astrid A   Vaudel Marc M   Lereim Ragnhild Reehorst RR   Barsnes Harald H   Myhr Kjell-Morten KM   Torkildsen Øivind Ø   Berven Frode S FS  

Journal of proteome research 20161026 1

In the current study, we conducted a quantitative in-depth proteome and deglycoproteome analysis of cerebrospinal fluid (CSF) from relapsing-remitting multiple sclerosis (RRMS) and neurological controls using mass spectrometry and pathway analysis. More than 2000 proteins and 1700 deglycopeptides were quantified, with 484 proteins and 180 deglycopeptides significantly changed between pools of RRMS and pools of controls. Approximately 300 of the significantly changed proteins were assigned to var  ...[more]

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