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Interactomes of neural cell adhesion molecule 1 and the metal ion transporter ZIP6 in mouse NMuMG epithelial cells with transforming growth factor beta 1-induced fibroblastoid morphology

ABSTRACT: The prion protein (PrP) evolved from the subbranch of ZIP metal ion transporters comprising ZIPs 5, 6 and 10, raising the prospect that the study of these ZIPs may reveal insights relevant for understanding PrP function. PrP and ZIP6 are required for the execution of a cellular program known as epithelial-to-mesenchymal transition (EMT). Polysialylation of neural cell adhesion molecule 1 (NCAM1) during EMT is also controlled by PrP. Here we report the ZIP6 interactome and ZIP6-dependent NCAM1 interactome in a mouse cell EMT model.

INSTRUMENT(S): Orbitrap Fusion ETD

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Epithelial Cell, Cell Culture

DISEASE(S): Disease Free

SUBMITTER: Declan Williams

LAB HEAD: Gerold Schmitt-Ulms

PROVIDER: PXD004685 | Pride | 2017-02-13

REPOSITORIES: Pride

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			Action	DRS
	NMuMGTGFb_wt_versus_ZIP6-ko_ZIP6_interactome_TMT_6_7_8_9_0_1_C18_1.raw	Raw
	NMuMGTGFb_wt_versus_ZIP6-ko_ZIP6_interactome_TMT_6_7_8_9_0_1_C18_2.raw	Raw
	NMuMGTGFb_wt_versus_ZIP6-ko_ZIP6_interactome_TMT_6_7_8_9_0_1_C18_3.raw	Raw
	NMuMGTGFb_wt_versus_ZIP6-ko_ZIP6_interactome_TMT_6_7_8_9_0_1_C18_4.raw	Raw
	NMuMGTGFb_wt_versus_ZIP6-ko_ZIP6_interactome_TMT_6_7_8_9_0_1_C18_5.raw	Raw

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Global quantitative proteomes of PrP-deficient mouse models

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The prion protein interactome in four mouse cell lines of distinct lineages

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