Proteomic profiling of sclerosis hippocampus revealed dysregulated packaging of vesicular neurotransmitters in temporal lobe epilepsy
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Brain, Neutrophil
DISEASE(S): Temporal Lobe Epilepsy
SUBMITTER: 
Wei Ge
LAB HEAD: Wei Ge
PROVIDER: PXD010543 | Pride | 2020-07-17
REPOSITORIES: Pride
Dataset's files
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Publications
Proteomic profiling of sclerotic hippocampus revealed dysregulated packaging of vesicular neurotransmitters in temporal lobe epilepsy.
Zhang Yusheng Y Liu Yifan Y Jia Yangjie Y Zhao Yuming Y Ma Chao C Bao Xinjie X Meng Xianbin X Dou Wanchen W Wang Xia X Ge Wei W
Epilepsy research 20200701
<h4>Purpose</h4>Temporal lobe epilepsy (TLE) is the most common type of epilepsy. Hippocampal sclerosis is the most distinctive pathological feature of TLE; however, its role in the pathogenesis of TLE remains to be clarified. We performed global protein expression analysis of hippocampus from TLE patients and controls, aiming to reveal the molecular signaling pathways related to TLE.<h4>Method</h4>Proteomic and bioinformatic analyses of the hippocampus were performed on 4 TLE and 4 control samp ...[more]
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