Dataset Information

Proteomic profiling of sclerosis hippocampus revealed dysregulated packaging of vesicular neurotransmitters in temporal lobe epilepsy

ABSTRACT: Proteomics and bioinformatic analyses of hippocampus were performed. High-resolution liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS), in combination with TMT-6plex quantification, was applied for global protein expression analysis. The proteomics results were validated by Western blot analysis.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Brain, Neutrophil

DISEASE(S): Temporal Lobe Epilepsy

SUBMITTER: Wei Ge

LAB HEAD: Wei Ge

PROVIDER: PXD010543 | Pride | 2020-07-17

REPOSITORIES: Pride

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Proteomic profiling of sclerotic hippocampus revealed dysregulated packaging of vesicular neurotransmitters in temporal lobe epilepsy.

Zhang Yusheng Y Liu Yifan Y Jia Yangjie Y Zhao Yuming Y Ma Chao C Bao Xinjie X Meng Xianbin X Dou Wanchen W Wang Xia X Ge Wei W

Epilepsy research 20200701

<h4>Purpose</h4>Temporal lobe epilepsy (TLE) is the most common type of epilepsy. Hippocampal sclerosis is the most distinctive pathological feature of TLE; however, its role in the pathogenesis of TLE remains to be clarified. We performed global protein expression analysis of hippocampus from TLE patients and controls, aiming to reveal the molecular signaling pathways related to TLE.<h4>Method</h4>Proteomic and bioinformatic analyses of the hippocampus were performed on 4 TLE and 4 control samp ...[more]

PMID: 32668389

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