Proteomics

Dataset Information

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Molecular determinants of tumor response to hyperthermia

ABSTRACT: Proteomic data from ovarian cancer cells (A2780 and SKOV3); treated cells with or without hyperthermia (46 deg C for 1 hr); 2 biological replicates for each cell line/condition

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Ovary

DISEASE(S): Ovarian Cancer

SUBMITTER: Matthew Monroe  

LAB HEAD: Anil K. Sood

PROVIDER: PXD005055 | Pride | 2018-10-22

REPOSITORIES: Pride

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Dataset's files

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Action DRS
Hyperthermia_Pool_01_28May15_Samwise_14-10-17.mgf Mgf
Hyperthermia_Pool_01_28May15_Samwise_14-10-17.pride.mgf.gz Mgf
Hyperthermia_Pool_01_28May15_Samwise_14-10-17.raw Raw
Hyperthermia_Pool_01_28May15_Samwise_14-10-17_ReporterIons.txt Txt
Hyperthermia_Pool_01_28May15_Samwise_14-10-17_msgfplus.mzid.gz Mzid
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Publications

Even though hyperthermia is a promising treatment for cancer, the relationship between specific temperatures and clinical benefits and predictors of sensitivity of cancer to hyperthermia is poorly understood. Ovarian and uterine tumors have diverse hyperthermia sensitivities. Integrative analyses of the specific gene signatures and the differences in response to hyperthermia between hyperthermia-sensitive and -resistant cancer cells identified CTGF as a key regulator of sensitivity. CTGF silenci  ...[more]

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